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Interestingly, atropine caused a significant reduction in ipamorelin-induced insulin secretion in diabetic but not in normal rats
GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically
Other cells were provided by co-authors or collaborators (SW480 and HT29 were provided by McDade and Longley (QUB)
Nunn E, Jaiswal N, Gavin M, et al
However, disturbances such as FFA levels, increased de novo lipogenesis, impaired fatty acid oxidation, and reduced lipid export collectively contribute to disrupted hepatic lipid metabolism [39]
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